Inside a Rare Case of Botox Resistance

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Over the past few years, there's been increased conversation around Botox resistance, where a person develops antibodies to the neurotoxin that block it from taking effect. Fifty-year-old Michelle Grant*, a front-office manager at Skin Wellness Dermatology in Birmingham, Alabama, considers herself "toxin resistant" after her routine neurotoxin injections stopped taking effect. "I'm just not freezing like I used to," she says. Grant's dermatologist, Corey L. Hartman, MD, FAAD, says this happens sometimes - a routine Botox user develops resistance to Botox or another form of botulinum toxin A - . . .

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